Recent studies have confirmed that the breast cancer was classified as two groups by their bormone dependency, namely, Estrogen Receptor Positive and Estrogen Receptor Negative groups. But, estrogen receptor assay could not be performed in Korea till now in spite of its clinical importance.
Some authors reported the plasma S.H.B.G. and E.R. in breast cancer had close correlation by their hormonal responses. As a preliminary study of estrogen receptor assay in Korean breast cancer, plasma S.H.B.G. capacity was checked and compared with normal control and breast cancer patients.
In normal control, the plasma S.H.B.G. capacity showed no significant difference between premenopausal and postmenopausal group or follicular and luteal phase of menstrual cycles.
In 53 cases of breast cancer patients, the plasma S.H.B.G. capacity showed significantly increase in luteal phase comparing with same phase of control group and also showed increasing tendency in postmenopause group.
Among the 23 cases of luteal phase breast cancer Patients, 13 cases showed above the upper limit of 99% confidence interval in normal control and among 11 cases of postmenopause breast cancer patients group, 7 cases showed also above the same upper limit in postmenopause control.
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